JOB OFFER

Position in the project: 

Doctoral candidate (PhD-student)

Scientific discipline:

biochemistry

Job type (employment contract/stipend):

stipend

Number of job offers: 

3

Remuneration/stipend amount/month (“X0 000 PLN of full remuneration cost, i.e. expected net salary at X 000 PLN”):

4 500 PLN stipend/month

Position starts on: 

October 1st, 2018

Maximum  period of contract/stipend agreement:

36 months

Institution:

Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland

Project leader:

Igor Konieczny

Project title:

Condition-dependent protease activation for targeted proteolysis in the regulation of DNA replication

Project is carried out within the Team 5/2017  programme of the Foundation for Polish Science

Project description:

The goal of this project is elucidation how, depending on conditions, proteases are structurally and spatially regulated to degrade essential replication proteins. The research will concentrate on bacterial Lon protease and its phosphate containing cofactors, contributing to the protease activities. By applying in vitro and in vivo experiments, including real-time, single-molecule and single-cell analysis with a variety of Lon proteins, substrates and cofactors, we expect to describe substrate-specific effects on Lon, and relate them to growth conditions. The cutting-edge techniques will be utilized for the description of the structure of Lon complexes. The research on molecular mechanisms of fundamental processes in bacteria is required due to the growing threat arising from the multidrug-resistant bacterial strains. Our goal is to provide data on Lon as a new target for new antimicrobial strategies based on the protease activity control. The project will be conducted with international collaboration of TEAM partners.

Key responsibilities include:

1.performing research using biochemical, genetic and molecular biology and computational techniques (independently and in collaboration with other team members)

2.participation in research design and data analysis

3.participation in preparation and writing of manuscripts

4.supervising younger researchers (Master students) involved in the project

5.active participation in lab meetings, departmental seminars and conferences

6.the project may require research stays in TEAM partners laboratories

Profile of candidates/requirements:

1.Master degree in one of the fields: biotechnology, biology, bioinformatics, chemistry

2.Solid laboratory training in biochemistry, molecular biology, microbial molecular genetics,

3.Training in bioinformatics, genomics, molecular phylogeny will be an additional advantage

4.Ability to communicate fluently in English (spoken and written)

5.Strong motivation to pursue scientific questions, creativity and analytical thinking

Required documents:

1.Motivation letter (in English)

2.CV (in English)

3.Recommendation letter, preferentially from the supervisor of the master project

We offer:

-work in active research team in an excellent scientific environment
-comprehensive cross-disciplinary training in molecular biology, biochemistry, bacterial genetics and protein structure/function predictions
-participation in scientific seminars and conferences

Please submit the following documents to:

team_konieczny@ug.edu.pl

Application deadline:

September 23th, 2018

For more details about the position please visit (website/webpage address):

      Laboratory molecular biology

Euraxess job/stipend offer (in case of PhD and postdoc positions):

https://euraxess.ec.europa.eu/node/333878

Due to the entry into force of Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016, we also require that your job advertisements include a clause requesting the candidate’s consent to the processing of his or her personal data by the institution which carries out the recruitment process.