JOB OFFER

Position in the project: 

Master student

Scientific discipline:

biochemistry

Job type (employment contract/stipend):

stipend

Number of job offers: 

2

Remuneration/stipend amount/month (“X0 000 PLN of full remuneration cost, i.e. expected net salary at X 000 PLN”):

2 000 PLN stipend/month

Position starts on: 

April 1st, 2019

Maximum  period of contract/stipend agreement:

15 months

Institution:

Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland

Project leader:

Igor Konieczny

Project title:

Condition-dependent protease activation for targeted proteolysis in the regulation of DNA replication

Project is carried out within the Team 5/2017  programme of the Foundation for Polish Science

Project description:

The goal of this project is elucidation how, depending on conditions, proteases are structurally and spatially regulated to degrade essential replication proteins. The research will concentrate on bacterial Lon protease and its phosphate containing cofactors, contributing to the protease activities. By applying in vitro and in vivo experiments, including real-time, single-molecule and single-cell analysis with a variety of Lon proteins, substrates and cofactors, we expect to describe substrate-specific effects on Lon, and relate them to growth conditions. The cutting-edge techniques will be utilized for the description of the structure of Lon complexes. The research on molecular mechanisms of fundamental processes in bacteria is required due to the growing threat arising from the multidrug-resistant bacterial strains. Our goal is to provide data on Lon as a new target for new antimicrobial strategies based on the protease activity control. The project will be conducted with international collaboration of TEAM partners.

Key responsibilities include:

1.perform research using biochemical, genetic and molecular biology and computational techniques (independently and in collaboration with other team members)

2.participate in research design and data analysis

3.actively participate in lab meetings, departmental seminars and conferences

Profile of candidates/requirements:

1.Bachelor degree in biotechnology, biology, bioinformatics, chemistry

2.Laboratory training in biochemistry, molecular biology, microbial molecular genetics

3.Training in bioinformatics, genomics, molecular phylogeny will be an additional advantage

4.Ability to communicate fluently in English (spoken and written)

5.Strong motivation to pursue scientific questions, creativity and analytical thinking

Required documents:

1.Motivation letter (in English)

2.CV (in English)

3.Recommendation letter, preferentially from the supervisor of the bachelor project

We offer:

-work in active research team in an excellent scientific environment
-comprehensive cross-disciplinary training in molecular biology, biochemistry, bacterial genetics and protein structure/function predictions
-participation in scientific seminars

Please submit the following documents to:

team_konieczny@ug.edu.pl

Application deadline:

October 20th, 2018

For more details about the position please visit (website/webpage address):

       Laboratory molecular biology

Euraxess job/stipend offer (in case of PhD and postdoc positions):

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